A structural view of protein methylation
نویسندگان
چکیده
منابع مشابه
Incorporating structural characteristics for identification of protein methylation sites
Studies over the last few years have identified protein methylation on histones and other proteins that are involved in the regulation of gene transcription. Several works have developed approaches to identify computationally the potential methylation sites on lysine and arginine. Studies of protein tertiary structure have demonstrated that the sites of protein methylation are preferentially in...
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Protein serine/threonine phosphatase 2A (PP2A), a conserved protein found in many species, plays an important role in various cellular processes including cell growth, differentiation, signal transduction, DNA replication, transcription, protein synthesis and apoptosis. Deregulation of PP2A methylation is linked to Alzheimer's disease and increased susceptibility to pathogen infections. PP2A wa...
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Background Genomic imprinting is a heritable and developmentally essential phenomenon by which gene expression occurs in an allele-specific manner1. While the imprinted alleles are primarily silenced by DNA methylation, it remains largely unknown how methylation is targeted to imprinting control region (ICR), also called differentially methylated region (DMR), and maintained. Here we show that ...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2002
ISSN: 0108-7673
DOI: 10.1107/s010876730208532x